Metronidazole or any other antibiotics mixed with your graft material: Does it enhance osseous regeneration results and minimize infections? Why do it at all?

Sun, 04/25/2010 - 02:53 — tamada

I have read a variety of articles about mixing antibiotics with your graft material for sinus and GBR grafting.
Is it more successful then no antibiotics, does it enhance results and minimize infections? What is your protocol? Why do it? What are the inidcations? Does it make a difference? What are the downside risks?
Where can we buy 0.5% metronidazole IV solution for reconstituting the grafting material for sinus lift in US?

Comments

Fri, 05/07/2010 - 05:16 — Dr. X

Mixing antibiotics with your bone graft works well.

I mix Metronizdazole with my graft. I use FDBA and Calcium sulfate. I use it in extraction sockets and GBR and feel it makes a difference.

I also started using it in my sinus grafts and feel 4 months post op my grafts are more consolidated.

Mon, 05/10/2010 - 17:01 — Eugene

Metronidazole

G'day mates,
My colleague makes up syringes from an I.V bag solution of Metronidazole BP 500mg/100ml bought from a local pharmacy.
Cheers,
Eugene

Tue, 05/11/2010 - 10:55 — Dr Chace Heatly

Metronidazole IV Bags: I agree with Eugene

This is exactly what I do I just draw from an IV bag into a syringe and mix with my bone graft.

I definetly see a difference in healing with my grafts since I started added antibiotic to it.

Thu, 05/27/2010 - 15:51 — Dr90210

Metronidazole 0.5% mixed in graft for sinus surgery

I been mixing Metronidazole within my grafts for sinus lifts and find 4 months healing the grafts are more consolidated.

There are several articles out there to support this concept.

Fri, 05/28/2010 - 06:06 — zivmazor

Metronidazole mixed with the graft

For those of you who need the reference
CONTROLLING SYSTEMATIC PERIOPERATIVE ANAEROBIC CONTAMINATION DURING SINUS-LIFT PROCEDURES BY USING METRONIDAZOLE: AN INNOVATIVE APPROACH

Joseph Choukroun, MD, Alain Simonpieri, DDS, Marco Del Corso, DDS, Ziv Mazor, DMD, Gilberto Sammartino, MD, PhD, and David M. Dohan Ehrenfest, DDS, MS, PhD
Implant Dent 2008;17:257–270